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Author information: Neoadjuvant treatment with a sequential anthracycline-taxane-based chemotherapy in combination with trastuzumab Herceptin is currently a preferred therapy for patients with HER2-positive breast cancer. Higher pCR rates are found in hormone-receptor-negative wmen.

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Patients with a pCR after chemotherapy and trastuzumab showed a significantly better outcome compared with those who did not have a pCR. The need for additional or alternate treatment options is great in patients who do not achieve a pCR. Addition of lapatinib Tykerb or pertuzumab Omnitarg to trastuzumab is a therapeutic option.

Recent findings suggest pCR might not be the appropriate surrogate for long-term outcome in patients with hormone receptor-positive and HER2-positive tumors. Jump to.

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